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This is a common issue that many printers have to struggle with on a daily basis.
While flexo is proving to be more than a match for offset it still uses a compressible plate and therefore allowances have to be made for sublimation and compression when creating the necessary color separations whether in hard copy or digital format.
Such areas that need particular attention are font sizes, intaglio and relief line dimensions, range of colors and screening technique and dot size and shape used.